Assessment of oxytocin level, glucose metabolism components and cutoff values for oxytocin and anti-mullerian hormone in infertile PCOS women

Background: Polycystic ovary syndrome (PCOS) is a common problem among women with infertility or subfertility. PCOS is associated with multiple complex hormonal and metabolic changes.Objective: Comparing oxytocin level and some other parameters between infertile women with or without PCOS, to evaluate the correlation between oxytocin with anti-mullerian hormone (AMH), Body Mass Index (BMI) and insulin resistance (IR).Materials and Methods: This cross-sectional study was performed on 80 PCOS and 81 non-PCOS women as the control group. Oxytocin, various hormones, Oral glucose tolerance test (OGTT) and Homeostatic model assessment of insulin resistance (HOMA-IR) were compared between two groups. Correlations between parameters were assessed by the spearman s rank correlation coefficient. Cutoff values for oxytocin and AMH in PCOS were calculated by the ROC-Curve and DeLong method.Results: The mean oxytocin level was statistically lower in the case group (p≤0.001). The mean BMI, AMH, HOMA-IR, fasting insulin and insulin 2-hr after 75-g glucose were significantly higher in the PCOS group. Oxytocin was negatively correlated to AMH when evaluated for all participants or only among controls. Moreover, oxytocin was negatively correlated to HOMA-IR among all participants. However, the relationship between oxytocin and BMI was not statistically significant. The calculated cutoff value for oxytocin was 125 ng/L and for AMH was 3.6 ng/mL in the PCOS group.Conclusion: The mean oxytocin level in the PCOS infertile women was lower than non-PCOS women. Oxytocin showed a significant reverse correlation with AMH and HOMA-IR.

کلیدواژه ها:

Anti-mullerian hormone ، Oral glucose tolerance test (OGTT) ، Oxytocin ، Polycystic ovary syndrome