Morphometric analysis of human oocytes does not predict embryos developmental outcomes: a time lapse study
محل انتشار: هشتمین کنگره بین المللی و جشنواره دانشجویی طب تولید مثل و سومین کنگره بین المللی ژنتیک تولید مثل
سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 345
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شناسه ملی سند علمی:
RMED08_148
تاریخ نمایه سازی: 21 مرداد 1398
چکیده مقاله:
Background: It is certain that the outcomes of intra-cytoplasmic sperm injection (ICSI) rely on the quality of selected oocytes for this procedure. Objective evaluation of oocyte quality is really a main issue of studying in assisted reproduction technology (ART) programs. Oocyte size and the quantitative properties of its components could suggest several clues about the oocyte quality.Objective: The aim of this prospective study was to evaluate the relationship between the morphometric parameters of metaphase II (MII) oocytes and morphokinetic behaviors of derived embryos in ICSI setting.Materials and Methods: The correlation of oocyte morphometry (whole oocyte), ooplasm, width of zona pellucid (ZP) and periviteline space (PVS), and first polar body (PB) with embryo morphokinetic variables including time of 2nd PB extrusion (tPB2), time of pronuclei appearance (tPN), time of pronuclei fading (tPNf), time of two to eight discrete cells (t2 to t8) and irregular cleavage events [uneven at 2 cells stage, cell fusion (Fu) and trichotomous mitoses (TM)] were assessed.Results: Only tPB2, t5 and t8 timings reversely linked to the ooplasm diameter (p=0.003, r=-0.12, p=0.001 r=-0.16 and p≤0.001 r=-0.36, respectively). But, there was insignificant relationship between oocyte morphometry and other morphokinetic parameters, irregular cleavage embryos as well as embryo arrest (p> 0.05).Conclusion: The data revealed that the oocyte morphometric parameters were not a powerful tool for prediction of embryo morphokinetic or embryo selection in ICSI cycles. However, ooplasm diameter may be useful for predicting some of the embryos cleavage timing.
کلیدواژه ها:
نویسندگان
A Faramarzi
Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran- Research and Clinical Center for Infertility, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
MA Khalili
Research and Clinical Center for Infertility, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran