Comparison of pregnancy outcomes in patients undergoing frozen embryo transfers with or without depot gonadotropin-releasing hormone agonist pretreatment

Background: Embryo cryopreservation is a safe and highly effective method to improve assisted reproductive technique (ART) outcomes. Protocols for endometrial preparation in frozen-thawed embryo transfer (FET) cycles include natural cycles and hormonal replacement cycles with or without gonadotropin-releasing hormone (GnRH) agonist. The superiority of one method over others remains controversial.Objective: The aim of the present study was to compare pregnancy outcomes between patients undergoing artificial endometrial preparation with or without GnRH agonist.Materials and Methods: One hundred ninety six patients undergoing artificial endometrial preparation for FET were retrospectively evaluated in the present study. According to pretreatment with GnRH agonist, patients were divided into 2 groups: patients who received half dose of GnRH agonist (decapeptyle, 1.87 mg) on day 21 of the preceding cycle (group A, n=93) versus who did not receive (group B, n=103).Results: Baseline characteristics of patients were not different between two groups. There was no significant different in endometrial thickness (p=0.92), total number of embryos transferred (p=0.86), number of blastocyst transferred (p=0.57) and number of grade A embryos transferred (p=0.64) between 2 groups. No significant differences were seen in implantation (15% vs. 14%, p=0.76), fertilization (74% vs. 74%, p=0.72), biochemical (36.6% vs. 34%, p=0.77) and clinical pregnancy rate (29% vs. 30.1%, p=0.87) between two groups.Conclusion: The results of present study indicated that artificial endometrial preparation without GnRH agonist seems to be as efficient as with GnRH agonist.

کلیدواژه ها:

Embryo transfer ، Gonadotropin-Releasing Hormone ، Pregnancy ، Cryopreservation