Comparison of free Beta-HCG and PAPPA in single normal and under IVF pregnancy at 12 weeks of gestational age

سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 408

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شناسه ملی سند علمی:

RMED08_214

تاریخ نمایه سازی: 21 مرداد 1398

چکیده مقاله:

Background: In some previous studies first trimester screening tests results are equivocal in IVF pregnancies and true interpretation is crucial.Objective: The purpose of this study was to compare Free Beta-HCG and PAPPA levels in single normal and under IVF pregnancies at 11-13w+6d of gestational age.Materials and Methods: In this observational study that was performed as a cohort, 300 consecutive single IVF pregnancies and 700 single normal pregnancies were enrolled at about 11-13w+6d of gestational age and Free Beta-HCG and PAPPA was compared across the groups.Results: The results in this study demonstrated that PAPPA (p=0.026) was significantly lower and beta-HCG (p=0.030) was significantly higher in IVF pregnancies. The other factors including NT (Nuchal Translucency) and CRL (crown to rump length) and demographic characteristics were not significantly differed across the groups (p> 0.05).Conclusion: This study showed that, PAPPA is lower and Free Beta-HCG is higher in single IVF versus normal pregnancies. It could be related to different placentation in ICSI technique because of alteration in oocyte cytoplasm. Therefore, these markers may be needed to be adjusted in ART conceptions. Further research should be done to obtain optimal cut-off for these markers in first trimester screening for Down syndrome in ART pregnancies.

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نویسندگان

M Talayeh

Department of Obstetrics and Gynecology, Infertility and Reproductive Health Research Center (IRHRC), Shahid Beheshti University of Medical Sciences, Tehran, Iran

R Taheripanah

Department of Obstetrics and Gynecology, Infertility and Reproductive Health Research Center (IRHRC), Shahid Beheshti University of Medical Sciences, Tehran, Iran