The Translational Landscape of Ground State Pluri-potency

Translational control plays a central role in regulation of gene expression and can lead to significant divergence between mRNA- and protein-abundance. The translational landscape of early mammalian development and its impact on cellular proteome, however, remains largely un-explored. By measur-ing the mRNA-abundance, mRNA-translation rate and protein expression, I will discuss the global changes in gene expression and the relative contributions of different layers of gene regula-tion during the transition of naïve to primed state pluripotency.