Association between Oligospermia and Testicular Cancer: Using Bioinformatics Analysis

سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 373

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شناسه ملی سند علمی:

RROYAN20_204

تاریخ نمایه سازی: 29 مهر 1398

چکیده مقاله:

Background: The incidence of testicular cancer has been in-creased all over the world during the last 4 to 5 decades, and in industrialized countries, testicular tumors are the most common malignant disease among men aged 20 to 34 years. A numberof reports have suggested a direct correlation between testicu-lar cancer and infertility among oligospermia or azoospermia. The aim of this study was to determine the common genes in oligospermia and testicular cancer as a therapeutic target for testicular cancer prevention in people with oligospermia.Materials and Methods: Genes involving in ologospermia and testis cancer obtained by Genecard database. Common genes were identified of these two diseases by the venn diagram. Original nodes were determined by string web server and cy-toscape software. Finally, KEGG database was used to deter-mined original nodes pathways involved in two disease.Results: The results of Genecards have shown 469 and 14102 genes are involved in oligospermia and testicular cancer re-ceptively. Among them, 422 genes are common between oli-gospermia and testicular cencer. TP53, INS, ALB, IL6 and EGFR has genes with highest degree. TP53 is the important gene in apoptosis, INS gene plays a role in Cell adhesion and Mismatch repair, ALB gene involved in metabolites metabo-lism and exogenous drugs, IL6 gene involved in block of dif-ferentiation and, EGFR gene mediated at cell proliferation.Conclusion: Pathways involved by genes with highest degree have an important role in progression of cancer. Therefore, de-termining the key targets can be very effective in preventing testicular cancer amongpeople with oligospermia.

نویسندگان

Z Dehghan

Cellular and Molecular Biology Research Center, Shahid Be-heshti University of Medical Sciences, Tehran, Iran. Department of Medical Biotechnology, School of Advanced Technology in Medicine, Tehran, Iran

M Salehi

Cellular and Molecular Biology Research Center, Shahid Be-heshti University of Medical Sciences, Tehran, Iran. Department of Medical Biotechnology, School of Advanced Technology in Medicine, Tehran, Iran

S Mohammadi Yeganeh

Cellular and Molecular Biology Research Center, Shahid Be-heshti University of Medical Sciences, Tehran, Iran. Department of Medical Biotechnology, School of Advanced Technology in Medicine, Tehran, Iran