Serum Adiponectin Levels and Phenotypes of Poly-cystic Ovary Syndrome: A Literature Review

Background: Adiponectin is a circulating protein produced by adipocytes. Circulating levels of adiponectin are inversely related to adipocyte mass. Low levels occur with insulin resist-ance, type 2 diabetes, metabolic syndrome, and obesity-related cardiovascular disease.The purpose of this article is to review the literature to determine what is known about the connection of adiponectin And phenotypes of PCOS.Materials and Methods: Comprehensive searches in the elec-tronic databases MEDLINE, EMBASE and Science Citation Index Expanded were conducted to identify published studies evaluating the association between Adiponectin and pheno-types of PCOS.Results: Studies have indicated that a significant relationship was found between adiponectin and phenotypes of Polycystic Ovary Syndrome.Conclusion: adiponectin serum concentrations vary according to the phenotypic expression of PCOS.The relationships be-tween adiponectin and insulin resistance and sensitivity, meta-bolic syndrome, and BMI in women with PCOS suggest that adiponectin could be used as a biochemical marker to identify phenotypes of PCOS.

کلیدواژه ها:

Adiponectin ، Polycystic Ovary Syndrome ، Pheno-types ، PCOS ،