Assisted Reproductive Technology and Risk of Au-tism

سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 297

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شناسه ملی سند علمی:

RROYAN20_429

تاریخ نمایه سازی: 29 مهر 1398

چکیده مقاله:

Background: In the last decades, prevalence of Autism Spec-trum Disorders (ASD) has dramatically increased. Though ge-netic factors are known to be involved in the etiology of ASD, research demonstrates that environmental factors such as con-genital rubella, maternal use of thalidomide, or valproic acid during pregnancy have been associated with autistic behaviors. Among the environmental factors, some authors reported as-sociation between ASD and assisted reproductive technology. Their hypothesis was the association between hormonal factors and ASD.This study conducted to determine assisted reproduc-tive technologies and its relation to autism.Materials and Methods: This review is based on a number of new Studies were identified by searching multiple literature da-tabases, including PubMed, SCOPUS, ISI and Google Scholar related to In vitro fertilization and risk of autism which pub-lished up to May 2019.Results: In the reviewed articles, opposite results were reported. Some reports have suggested an increased risk of ASD with use of infertility treatments but most of these studies have been case-control and retrospective without rigorous confirmation of expo-sures or have had very small case numbers and did not adjust for potential confounders. For example increased parental age which has been associated with both use of infertility treatments and having a child with ASD, in some studies have not been con-sidered. Also in some studies a higher risk of ASD in children born after assisted conception might be related to the higher rates of multiplicity, preterm birth and low birth weight deliveries. Against, few studies reported that assisted reproductive technol-ogy is not a strong independent risk factor for ASD and finally one study has reported favoring a protective role of ART.Conclusion: According to contradictory results, prospective, large and high-quality studies are still needed.

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نویسندگان

F Safdari

Student Research Committee, School of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran

NS Nekuei

Student Research Committee, School of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran

S Zangeneh

Student Research Committee, School of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran