Investigate the effects of folic acid supplementation on homocysteine levels in women with preeclampsia

Pre-eclampsia is a syndrome which is characterized by the increase in blood pressure above 033053, oedema and proteinuria, and is one of the leading causes of maternal death and of complications in pregnancy that can occur in the second half of pregnancy.Approximately 53 % of pregnant women in developing countries and 9 % of pregnant women worldwide are affected, and it is the second leading cause of maternal death in developing countries, including Iran . Homocysteine (2-amino-4-mercapto-butyric acid), is a sulphur-containing amino acid without special codon and is created by an essential amino acid methionine demethylation from the diet. Homocysteine has sulphydryl group, which makes it more susceptible to other thiol oxidation and disulphide formation. Folic acid is water-soluble vitamin, and despite the need to get pregnancy to avoid disruption process of the nervous system of the fetus, NTD for antioxidant effects reduces oxidative stress, and the concentration and oxidation of homocysteine, therefore, diet and supplements during pregnancy is important.This case-control study was conducted on healthy pregnant women visiting Taleghani and Al Zahra hospitals in Tabriz, Iran, as well as on women with pre-eclampsia admitted to these two hospitals. Fifty-eight samples were selected as controls and 6+ subjects were selected as cases. The blood samples were prepared with their consents. Parameter measured included homocysteine concentration in blood. In addition, a questionnaire was completed to collect information on age, gestational stage, height, weight, weight before pregnancy and folic acid (B9) intake. The results in this study are based on the inhibition of confounding variables and indicate significant differences in homocysteine status. The people, who received folic acid supplements during pregnancy were 20, and finally 506 of them were diagnosed with gestational hypertension, have been hospitalized, and 406 of them were in the control group.Elevated homocysteine levels can be considered as a factor in the etiology of preeclampsia. The type of diet and dietary antioxidants, including folic acid, in reducing homocysteine-induced oxidative stress, and improve preeclamptic women is important.

کلیدواژه ها:

homocysteine ، folic acid ، pre-eclampsia