Frequency of sabA Gene in Helicobacter pylori Strains Isolated From Patients in Sanandaj, Iran

Background: The importance of sialic acid binding adhesin (sabA) as a new outer membrane protein in gastroduodenal diseases has been recognized. The prevalence rate of sabA gene varies in different geographic areas. The aim of this study was to determine the frequency of sabA gene in Helicobacter pylori (H. pylori) strains isolated from different clinical outcomes in sanandaj, Iran. Materials and Methods: This observational study was carried out on 50 patients.Biopsy specimens were evaluated for the presence of Helicobacter pylori through rapid urease test and PCR. The sabA genotype was determined by PCR in H. pylori strains. Results: H. pylori isolates were recovered from 23 patients with duodenal ulcer (DU; n =4), gastric ulcer (GU; n =6 ( , and gastritis (G; n = 13). The frequency of sabA gene in H. pylori strains was33.24% in gastric ulcer, and 69.24% in gastritis and 25% in duodenal ulcer. Conclusion: The current study demonstrated that the sabA gene status was not associated with clinical diseases.Therefore, further investigations are needed

کلیدواژه ها:

sabA ، Helicobacter pylori ، digestive disease