Green synthesis and characterization of CoFe2O4/SiO2 nanocomposites for atenolol delivery

Background and Objective: Drug delivery systems can be reduce the minimum effective dosage of the drug compared to the usual route and thus reduces the toxic side effects of the drug. Many forms of ceramic drug delivery systems (MCM-41, SBA-15 and etc.) have been used to carry various types of drugs such as proteins, steroids, hormones, amino acids, phenolic, vaccines, antibiotics and anti-cancer drugs. Atenolol has been used to treat angina and hypertension, either alone or with other antihypertensive. Despite its usefulness, it shows some side effects such as diarrhea and nausea in some patients. A process for slow release of atenolol in intestine is helpful to prevent such side effects [1-3]. Materials and Methods: In this study, simple and rapid sonochemical method for preparing of CoFe2O4/SiO2 nanocomposites has been developed in presence of various fruits extract (sucrose, maltose) as a green capping agent. The structure of each new synthesized nanocomposites was fully characterized by FT-IR, XRD, SEM, TEM, VSM and EDS. The prepared nanocomposites was used for storage/slow release study of atenolol. Findings:TEM analysis was used in order to determine the particle size and morphology of nanocomposite. TEM images of CoFe2O4/SiO2 nanocomposites shows that the nanocomposites with uniform size around 60 nm and sphere morphology were synthesized. Therefore, the as-prepared CoFe2O4/SiO2 nanocomposites could be an efficient platform for atenolol delivery. Conclusion: The aim of this work was synthesis and characterization of CoFe2O4/SiO2 nanocomposites through sonochemical method and elucidates the underlying drug release capability of magnetic nanocomposites. Modification was performed by amino groups and this system was used as a drug controlled delivery systems of atenolol in simulated body fluid (SBF). Increasing pH value to 8 causes increase in the drug release.

کلیدواژه ها:

Magnetic nanocomposite ، Drug delivery ، Atenolol.