Background: Sexual dysfunction is common among women after childbirth. Sexual dysfunction can lead to anxiety, depression and stress. Majority of these problems can be treated in early stages with counseling. The aim of this study was to assess the effectiveness of PLISSIT model on depression, anxiety and stress in women with sexual dysfunction after childbirth.Methods: This clinical trial was performed on 80 women in 2017 within the period of 4 weeks to 6 months following childbirth (obtaining a score equal to or less than 28 from the FSFI) that they didn’t have any sexual dysfunction before and during the pregnancy. PLISSIT model comprises of 4 levels 1-Permission; 2-Limited Information; 3- Specific Suggestions; 4-Intensive Therapy. The study subjects were randomly assigned to two groups of PLISSIT and control groups. Subjects in PLISSIT group attended two counseling sessions in 2 weeks (one session per week) and Control group received routine care. The research instruments also included a demographic and sexual characteristics information questionnaire and female sexual function index (FSFI) and Depression Anxiety Stress Scales-21(DASS-21). The female sexual function, anxiety, stress and depression in PLISSIT and Control group was evaluated before intervention and 4 weeks after the last session in PLISSIT group and 4 weeks after receiving routine care in Control group the data analysis was conducted using the SPSS Ver.24 with independent t-test, Analysis of covariance and Mann-Whitney U test and considering a significance level of 0.05.Results: The mean and the standard deviation of the DASS-21 total score in control group at baseline was 9.2 -9.5 and 4 weeks after the last session was 8.7 -4.3 and in the PLISSIT group at baseline was 9.6-7.5 and after intervention was 3.3-2.9, the results of Mann-Whitney showed that such a difference was significant (P=0.026). The results of covariance analysis indicated that, by controlling the intervening variables such as DASS-21 total score before intervention and sexual function changes, the DASS-21 score in the intervention group decreased compared to the control group Conclusion: The PLISSIT model decrease DASS-21 total score in women with sexual dysfunction after childbirth.Message for policymakers: variability in the relationship between sexual function and depression and postpartum depression is dependent on culture and May different in countries. But there is a very strong connection between the weak relationship with the spouse and depression after child birth. The PLISSIT model decrease DASS-21 total score by Improvement the sexual dysfunction in women with sexual dysfunction after childbirth. PLISSIT model can be used as a framework by healthcare providers particularly midwives as a counseling approach with ease of implementation to decrease mild postpartum depression, anxiety and stress.