Application of Fucoidan Extracted from Algae in Wound Healing and Tissue Regeneration

سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 556

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شناسه ملی سند علمی:

WTRMED05_021

تاریخ نمایه سازی: 5 آذر 1397

چکیده مقاله:

Wound healing is a complex biological process that depends on the condition of the wound, the patient s health and physical and chemical support. The discovery of natural ingredients has proven to be remarkable for ideal skin regenerating, including highly diverse marine macromolecules, which are a great source of tissue Engineering substitute for wound healing. So far, research has proven that marine derivatives of macromolecules such as chitin, chitosan and fucoidan have the potential to significantly accelerate the process of wound healing and tissue regeneration. Fucoidan is a sulfated polysaccharide found in the algae cell walls. Reports have demonstrated that fucoidan has a remarkable role in wound healing and skin formation replacing tissue engineering. Fucoidan derived from the Fucus vesiculosus species and the chitosan composite film has been shown to improve skin wound, including the regeneration of papillary forms of the skin, epithelial reformation, and the rapid closure of the rabbit s wound surface. Similar results have been obtained from chitosan-fucoidal hydrogels that effectively protect against Rat s wound Studies have shown that UV-B induces MMP-1, which fucoidan inhibits its expression at the level of mRNA and protein. The results have shown that algae fucoidan has a potential role in reducing the risk of some inflammatory pathologies, including degradation of extracellular matrix by MMP-1. Fucoidan attach to the fibroblast growth factor and protect them from proteolysis. It seems that its therapeutic mechanism, due to the binding of its glycosaminoglycan, to steromal derived factors (SDF-1), is a precursor to brain stimuli that can contribute to angiogenesis with vascular endothelial growth factor and fibroblast growth factor Therefore, Fibroblast growth factor-2 containing fucoidan-chitosan hydrogel microcomplexes are effective and available for ischemic diseases. In general, extraction of bioactive compounds such as algal derived sulfate polysaccharides can play an important role in the development of cosmetic industry.

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نویسندگان

Arghavan Hosseinpouri

MSc of Cellular and Molecular Biology , Persian Gulf University, Bushehr, Iran

Mahdi Mohammadi

MSc of Cellular and Molecular Biology , Persian Gulf University, Bushehr, Iran

Narges Obeidi

MSc of Cellular and Molecular Biology , Persian Gulf University, Bushehr, Iran