Chitin-Based Materials and Wound Tissue Engineering

سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 484

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شناسه ملی سند علمی:

WTRMED05_033

تاریخ نمایه سازی: 5 آذر 1397

چکیده مقاله:

Tissue engineering provides opportunities to reconstruct living tissues and organs where significant amounts of tissue have been lost. Here, we aimed to mention the overall properties of an ideal bio-scaffold which is intended to regeneration and repair of wounds. Recently, B-chitin/nanosilver composite scaffolds were prepared for wound tissue engineering applications using B-chitin hydrogel with silver nanoparticles. The antibacterial, blood clotting, swelling, cell attachment and cytotoxicity studies of the prepared composite scaffolds were evaluated. The prepared B-chitin/nanosilver composite scaffolds were bactericidal against E. coli and S. Aureus and showed good blood clotting ability as well. Cell attachment studies using Vero (epithelial cells) showed that the cells were well attached on the scaffolds. Similarly, alpha-chitin/nanosilver composite scaffolds showing similar results were developed for wound tissue engineering applications using alpha-chitin hydrogel with silver nanoparticles. These results suggested that chitin/nanosilver composite scaffolds could be potential candidates for wound tissue engineering. Despite these concerns, using bio-scaffold and tissue engineering investigation provides opportunities and great progress these days. It should be mentioned to use bio-scaffolds which diminish the requisite for organ replacement, reduce present unalterable side effects, and develop the quality of patients life.

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نویسندگان

Farahnaz Moattari

Ph.D, Cell & Developmental Biology, Kharazmi University, Tehran, Iran

Mehrnaz Moattari

Ph.D, Cell & Developmental Biology, Kharazmi University, Tehran, Iran

Gholamreza Kaka

Ph.D, Cell & Developmental Biology, Kharazmi University, Tehran, Iran

Homa Kouchesfehani

Ph.D, Cell & Developmental Biology, Kharazmi University, Tehran, Iran