Chitosan Nonocomposite Scaffolds and Wound Healing

Chitosan-based scaffolds are used as a natural material in regenerative medicine. Because it has anti-bacterial, anti-fungal and non-toxic properties. So, using chitosan-based biomaterials are useful in wound healing. B-chitin/HA nanocomposite scaffolds were synthesized from a mixture of B-chitin hydrogel and nHA by freeze-drying technique. The cytocompatibility of the nanocomposite scaffolds was studied using Vero, NIH 3T3 and HDF cells. The results indicated non-toxicity with enhanced attachment and proliferation of these cells onto the nanocomposite scaffolds. Similar results were observed with alpha-chitin/HA nanocomposite scaffolds synthesized from alpha-chitin hydrogel and nHA by freeze-drying approach. These results essentially signify that the synthesized nanocomposite scaffolds can serve as potential candidates for wound tissue engineering. Similar concepts could be thought of for regenerating other tissues or organs using chitosan scaffolds. Further studies are needed to demonstrate the potential uses of chitosan scaffold in the tissue engineering/regenerative medicine area.

کلیدواژه ها:

Chitosan ، Nanocomposite ، Tissue Engineering ، Wound