Infection Control and Burn Wound Healing in Rats with Essential Oil

Background: Burn wound is a good place to develop resistant to infections. In this study, the use of diluted plant essential oil for controlling bacteria in the burn was investigated. Materials and Methods: Grade 2 ulcer burns to specific dimensions in three groups of rats after anesthesia. Confirmation of bacterial susceptibility to the diluted essential oil through dilution Micro dilution method and disk diffusion. In this design, after inoculation of Pseudomonas bacteria, the first group was treated with essential oil and the second group was treated with silver nitrate ointment and the third group had no treatment. During the treatment and debridement of the wounds, the presence of infection and its symptoms as well as inflammation and healing rate were studied. A warm coloring and microbial culture were performed and biopsies from the wounds of two groups of extract and silver nitrate ointment were subjected to histological examination. Results: In the dilution Micro dilution method, the concentration of 5 mg / ml was obtained as MIC. The results and observations were performed in three treatment groups with extract and treatment of silver and the group without treatment were microscopic and macroscopic, and the physiological signs of their mice and their wounds, as well as pathological examination. In the Silverstone group, the wound healing rate was very low due to the presence of more bacteria and inflammation. Oscars were not easily debrided due to inflammation. In the control group, the scar was formed, but the recovery rate was very low and no similar symptoms were observed in the extract and silver groups. Conclusion: It was proved that Oregano essential oil was able to control first and second degree burn wound infections in vistar rats. This material is recommended for the clinical trials on human.

کلیدواژه ها:

Infection Control ، Burn ، Wound Healing ، Essential Oil