Cold plasma is a novel method to treat diabetic foot ulcer infection

سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 505

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شناسه ملی سند علمی:

WTRMED06_197

تاریخ نمایه سازی: 5 بهمن 1398

چکیده مقاله:

Background: Cold atmospheric plasma (CAP) is shown to decrease bacterial load in chronic wounds. It is also presented as a novel approach in healing the wounds in both in vitro and in vivo experiments.Objective: We aimed to implement the first randomized clinical trial in use of CAP in diabetic foot ulcers.Methods: Patients with diabetic wound (n=44) were randomized to receive standard care (SC, n=22) without or with CAP applied three times a week for three consecutive weeks (SC+CAP, n=22). CAP was generated from ionized helium gas in ambient air and driven by high voltage (10 kV) and high frequency (6 kHz) power supply. The primary outcomes were wound size, number of cases reached wound size of <50%, and bacterial load over three weeks of treatment.Results: Treatment with CAP was effective in reducing the fraction of wound size (p=0.02). After 3 weeks, the number of wounds that reached the fraction of wound size of ≤ 50% was significantly more in SC+CAP group (77.3%) compared with the SC group (36.4%) (p = 0.006). The mean of fraction of bacterial load counts in each session ‘after CAP exposure’ was significantly less than ‘before exposure’ measures.Conclusion: CAP could be an effective method for accelerating wound healing in diabetic foot ulcers. It also exerts immediate antiseptic effects, which seems not to last for a long time.

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نویسندگان

Mohammad Reza Amini

Diabetes Research Center, Tehran University of Medical Sciences, Tehran, Iran