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گواهی نمایه سازی مقاله Synthesis of 2-(N-morpholino methyl)-1-piperidino-1-phenyl cyclohexane as a newanalogue of phencyclidine

عنوان مقاله: Synthesis of 2-(N-morpholino methyl)-1-piperidino-1-phenyl cyclohexane as a newanalogue of phencyclidine
شناسه (COI) مقاله: CAAT05_020
منتشر شده در پنجمین همایش ملی کاربردهای شیمی در فناوری های نوین در سال ۱۳۹۴
مشخصات نویسندگان مقاله:

M.R Darvich - Department of chemistry,faculty of science,Islamic Azad UniversityYadegar-e-Imam Khomeini (RAH) Branch ,Tehran.Iran.
Z Khanjari - Department of chemistry,faculty of science,Islamic Azad UniversityYadegar-e-Imam Khomeini (RAH) Branch ,Tehran.Iran.
E Mobarhan - Department of chemistry,faculty of science,Islamic Azad UniversityYadegar-e-Imam Khomeini (RAH) Branch ,Tehran.Iran.

خلاصه مقاله:
aryl cyclohexyl amines were synthesized for evaluation as central nervous depressants [1]. In this research, we synthesized 2-(N-morpholino methyl)-1-piperidino-cyano cyclohexane from 2-(N- morpholino methyl) cyclohexanone and KCN [2,2]. The new derivative of 1-aryl cyclohexyl amines was prepared from this nitrile by replacement of the cyano group by aryl using Grignard reagent [4]. The structure of nitrile compound and product of reaction this nitrile with Grignard reagent was confirmed by MASS,IR,12C-NMR,1H-NMR.

کلمات کلیدی:
Phencyclidine, Amino nitriles, Grignard reaction

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