Hamidreza Agha Heydarali Naghash - Karaj Branch, Islamic Azad University,Karaj,Iran
Ali Salehzadeh - Department of Biology, Rasht Branch, Islamic Azad University, Rasht, Iran
Bahareh Abbasi - National Institute of Genetic Engineering and Biotechnology (NIGEB),Tehran,Iran
Nafiseh Ansarinejad - Iran University of Medical Sciences, Tehran,Iran

Breast cancer (BC) is one of the most commonly occurring epithelial malignancies in women, with an estimated 1 million new cases and over 400,000 deaths annually worldwide. Despitemuch investigation, the causes are not yet fully understood. Accumulated evidence suggests that multiple genetic and environmental factors, as well as the interplay between these factors,determine the phenotype.Single nucleotide polymorphisms (SNPs) lead to genetic differences in breast cancer (BC) susceptibility among women from different ethnicities. The present study aimed at investigating the involvement of SNPs at chromosome 5p12.A genome-wide association study, conducted among women of European ancestry, has identified two single-nucleotide polymorphisms (SNPs) rs4415084 (T/C) and rs10941679 (A/G) at chromosome 5p12 were associated with risk of breast cancer, suggesting that genetic variants in this region may have a role in the development of breast cancer.The single nucleotide polymorphism 5p12-rs10941679 has been found to be associated with risk of breast cancer, particularly estrogen receptor (ER)-positive disease.Another study direct by Thomas et al.9 confirmed the single-nucleotide polymorphism.(SNP) rs4415084 might affect breast cancer risk in the European population. Both rs4415084 and rs10941679 conferred significantly greater risks of ER-positive breast cancer than of ER-negative tumors.The biological mechanism through which genetic variations in 5p12 influences BC risk remains unclear. To investigate the associations between SNPs at 5p12 and risk of breast cancer in the Persian women, we will conduct in 5p12 polymorphisms (rs4415084 and rs10941679) using a genotype these SNPs with a case–control study in the Iranian population.

Breast cancer ,5p12,SNP,genetic variations