Mehdi Allahbakhshian farsani - Laboratory hematology and blood bank department, Faculty of allied medical science, Shahid beheshti university of medical science, Tehran, Iran
Kosar Fateh - HSCT Research center, Shahid beheshti university of medical science, Tehran, Iran
Mohammad Hossein Mohammadi geravand
Abbas Hajifathali

Evs are heterogeneous enclosed vehicles which are sized between15 nanometers to 10 microns in diameter, carrying cargo including lipids, proteins, and nucleic acid. Thus, they participate in cellular communication. Ev’s shedding from plasma membrane with the purpose of delivering their messages to the neighbor cells. Regarding this, EVs might be released more by malignant cells with the aim of using this tool to shape microenvironment in the benefit of tumor growth and survival. Recent studies indicated that malignant cells may affect their microenvironment due to the assemble of neoplastic molecules in their Evs content. Considering that these vesicles are enriched with specific components in malignant cells, Moreover, these cells release Evs in all body fluids candidly such as saliva, blood, urine, plasma, and semen fluids. Consequently, they can be used as particular biomarkers for risk stratification and diagnostic of cancer cells which is an application in personalized medicine. This investigation touches the role of extracellular vesicles in personal leukemia therapy.