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گواهی نمایه سازی مقاله Effect of Polymer Blending on Morphology and Initial Burt Release of an in Situ-Forming Drug Delivery System

عنوان مقاله: Effect of Polymer Blending on Morphology and Initial Burt Release of an in Situ-Forming Drug Delivery System
شناسه (COI) مقاله: ISPST10_680
منتشر شده در دهمین سمینار بین المللی علوم و تکنولوژی پلیمر در سال ۱۳۹۱
مشخصات نویسندگان مقاله:

Milad Jafari-Nodoushan - Science Department, Iran Polymer and Petrochemical Institute, Tehran, Iran.
Tannaz Ebrahimi - Science Department, Iran Polymer and Petrochemical Institute, Tehran, Iran.
Hamid Mobedi - Science Department, Iran Polymer and Petrochemical Institute, Tehran, Iran.
Jalal barzin - Science Department, Iran Polymer and Petrochemical Institute, Tehran, Iran.

خلاصه مقاله:
Key issues in designing drug delivery systems are the avoidance of bursting effects and the attainment of controlled, in vivo release profiles over the lifetime of the depot. In thisregard, polymeric membrane-based delivery systems play a significant role in drug delivery systems. These systems are mostly rectified via using additives, which might have nocuous side effects [1, 2]. The aim of the present work is to modify the release pattern of in-situ forming implants containing Naltroxone, using different poly(D,L-lactide-coglycolide) (PLGA) blends, without incorporating any additional chemicals.

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