A Zarghami - Department, University Sciences and Research Branch, Islamic Azad University, P.O. Box 146366-7661, Tehran, Iran
I Haririan - Department, of Pharmaceutics, Tehran University of Medical Science, P.O. Box 14155-6451, Tehran, Iran
A Heidarinasab - Department, University Sciences and Research Branch, Islamic Azad University, P.O. Box 146366-7661, Tehran, Iran

In this study, poly (ethylene oxide)/Chitosan(CS), poly(ε-caprolactone)/Chitosan and poly(vinyl alcohol)/Chitosan composite nanofibers were prepared using electrospinningtechnique.Chitosan is a multifunctional biodegradable polycationic biopolymer that has uses in a variety of differentindustrial applications. But, the electrospinning of Chitosandue to the low solubility, low stability and low mechanical properties did not produce the fibrous structure[1]. Therefore,the polymers such as poly (ethylene oxide) (PEO), poly(vinyl alcohol) (PVA) and poly(ε-caprolactone)(PCL) were blendedto Chitosan to improve the electrospinning ability of Chitosan. Furthermore, the optimization of ratio of Chitosan to PEO, PVA and PCL is very important to form the homogeneous andthinner fibers[2]. Therefore, PEO/Chitosan, PCL/Chitosan and PVA/Chitosan blend solutions in various ratios were studied for electrospinning into nanofibers