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گواهی نمایه سازی مقاله A Comparison between Therapeutic Effect of Granulocyte Colony-stimulating Factor and Methylprednisolone in Treatment of Patients with Acute Traumatic Spinal Cord Injury

عنوان مقاله: A Comparison between Therapeutic Effect of Granulocyte Colony-stimulating Factor and Methylprednisolone in Treatment of Patients with Acute Traumatic Spinal Cord Injury
شناسه (COI) مقاله: JR_IJN-2-1_001
منتشر شده در مجله جراحی مغز و اعصاب ایران در سال ۱۳۹۵
مشخصات نویسندگان مقاله:

Shahrokh Yousefzadeh-chabok - MD, Professor of Neurosurgery, Guilan Road Trauma Research Center, Guilan University of Medical Sciences, Rasht, Guilan, Iran
Babak Alijani - MD, Associate Professor of Neurosurgery,Guilan Road Trauma Research Center, Guilan University of Medical Sciences, Rasht, Guilan, Iran
Mohammadreza Emamhadi - MD, Associate Professor of Neurosurgery,Guilan Road Trauma Research Center, Guilan University of Medical Sciences, Rasht, Guilan, Iran
Hamid Behzadnia - MD, Assistant Professor of Neurosurgery, Guilan Road Trauma Research Center, Guilan University of Medical Sciences, Rasht, Guilan, Iran

خلاصه مقاله:
Background & Aim: Spinal cord injury (SCI) is one of the worst kinds of traumatic injuries with remarkable social and economiceffects on communities.Methods & Materials/Patients: In this prospective randomized clinical trial, 122 patients with traumatic spinal cord injury wereadmitted to Poursina hospital within 48 hours of injury to compare granulocyte colony stimulating factor (G-CSF) and high-dosemethylprednisolone as neuroprotective therapy.Results: In this research, 122 patients were studied out of whom 62 patients were included in the granulociote colony-stimulatingfactor (G-CSF) group with a mean age of 40.4, and 60 patients in the methylprednisolone group with an average age of 40.10 years.55 out of 122 patients (45%) were completely paralyzed (Grade AIS:A) and 67 (55%) were with incomplete spinal injury (GradeAIS:B,C,D). The average American spinal injury association (ASIA) sensory scores in the two groups were similarly compared inthe same four time intervals, and p values were 0.7, 0.3, 0.2, and 0.1. They were not statistically significant.Conclusion: According to the results, the G-CSF was shown to be beneficial in average ASIA motor and sensory scores in the twogroups of male patients at six months of onset of G-CSF treatment (p value=0.04), and average ASIA motor scores improvement inthe falls subgroup patients also differed significantly within six months of onset of G-CSF treatment (p value=0.03). A multicentreprospective randomized clinical trial to compare the placebo effect with G-CSF protocol s treatment, and also assessment of thecost benefits of the common medical treatment versus G-CSF are n eeded.

کلمات کلیدی:
Granulocyte; Colony-stimulating; Methylprednisolone; Treatment

صفحه اختصاصی مقاله و دریافت فایل کامل: https://www.civilica.com/Paper-JR_IJN-JR_IJN-2-1_001.html