Hossein Ayatollahi - Dept. of Biochemistry and Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Maliheh Hasanzade - Dept. of Obstetrics and Gynecology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Mahdi Farzadnia - Dept. of Pathology; School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Mahdi Khabbaz Khoob - Dept. of Epidemiology, School of Paramedicine, Mashhad University of Medical Sciences, Mashhad, Iran

Background and Objective: The aim of this study was to determine the level of plasma high sensitive c-reactive protein (hs-CRP) in preeclampsia and to compare hs-CRP levels between normalpregnant women, mild preeclamptic, and severe preeclamptic women. Materials and Methods: Serum hs-CRP levels were investigated in 40 cases of normal pregnantwomen, 37 cases with mild preeclampsia and 38 cases with severe preeclampsia in the third trimesterof pregnancy. Venous blood samples were collected at admission to the hospital at least 6h before delivery for measurement of hs-CRP by immuno turbidometric method. The student t-test was usedfor comparison of proportions. Results: There were significant difference in the means serum hs-CRP between normal pregnantwomen and mild preeclamptic women (P<0.05). Serum concentration of hs-CRP were significantlyhigher in severe prceclampsia (p<0.05) than normal pregnancy. There were also significant differences in hs-CRP levels between mild and severepreclampsia (P<0.05). Conclusion: We found higher levels of hs-CRP in mild and severe preeclampsia than normalpregnancy and also these results suggest that hs- CRP are increased more in severe preeclamsia than mild preeclampsia , and may be useful in prediction and diagnosis of the severity of preeclampsia

C-reactive protein receptor, Pre-Eclampsia, Pregnancy