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Detection of Extended Spectrum Beta Lactamase Producing Salmonella spp. and Multidrug Resistance Pattern

عنوان مقاله: Detection of Extended Spectrum Beta Lactamase Producing Salmonella spp. and Multidrug Resistance Pattern
شناسه ملی مقاله: JR_IJP-4-3_006
منتشر شده در شماره 3 دوره 4 فصل تابستان در سال 1388
مشخصات نویسندگان مقاله:

Gholamreza Irajian - Dept. of Microbiology, Iran University of Medical Sciences, Tehran, Iran
Reza Ranjbar - Molecular Biology Research Center, Medicine Faculty, Baghiatollah University of Medical Sciences, Tehran, Iran
Ali Jazayeri Moghadas - Dept. of Microbiology, Medicine Faculty, Semnan University of Medical Sciences, Semnan, Iran

خلاصه مقاله:
Background and Objectives: Salmonella infections are endemic in many developing countries with poor sanitary conditions, but emerge sporadically as a serious public health threat in developedcountries. Infections with multidrug resistant (MDR) strains of Salmonella have been associated withtreatment failures. Salmonella spp. resistant to extended spectrum cephalosporins are increasing in prevalence worldwide. The aim of this study was to determine the antimicrobial susceptibility,multidrug resistance and extended spectrum beta lactamase (ESBL) production among clinicalisolates of Salmonella spp. during 2007 in Tehran, Iran. Patients and Methods: In this cross-sectional study, fifty Salmonella spp. were identified by API20E system and serotyped by the slide agglutination test. Disk diffusion test was performed. Double disk synergy test was used as a screening test for ESBL production, using disks of cefotaxime and ceftazidime with and without clavulanic acid. Results: From 50 Salmonella spp. 12 (24%) were S. enterica serogroup paratyphi B, 24 (48%) S. enterica serogroup paratyphi C and 14 (28%) were S. enterica serogroup Typhi. The mostsusceptibility and resistance were observed to ceftazidime (98%) and amoxicillin-clavulanic acid (96%), respectively. 28(56%) were resistant to 5 or more antibiotics. ESBL production was detectedby double disk synergy test in one isolate (2%). Conclusion: Results showed increase in antibiotic and multidrug resistance pattern of Salmonella spp. comparing to previous studies in Iran and other countries. It seems that this is the first report of Salmonella spp. ESBL producing in Iran.

کلمات کلیدی:
Salmonella, antibiotic susceptibility, Multidrug Resistance, ESBL, Double disk synergy, Iran

صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/302661/