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گواهی نمایه سازی مقاله Investigation of the Antibacterial Effect of Venom of the Iranian Snake Echis carinatus

عنوان مقاله: Investigation of the Antibacterial Effect of Venom of the Iranian Snake Echis carinatus
شناسه (COI) مقاله: JR_IJVST-2-2_003
منتشر شده در دوفصلنامه علوم و فنون دامپزشکی ایران در سال ۱۳۸۹
مشخصات نویسندگان مقاله:

Atena Jami al ahmadi - Department of Basic Sciences
Behrooz Fathi - Department of Basic Sciences
Abdoula Jamshidi - Department of Food Hygiene and Aquaculture,School of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran
Hosein Zolfagharian - Razi Vaccine and Serum Research Institute, Tehran, Iran

خلاصه مقاله:
Although some venoms and their isolated compounds have been shown to have antibacterial properties, most have not been investigated for such activity. Echis carinatus is one of the most venomous snakes in the world and has an effective haematotoxic venom that destroys endothelial cells and causes haemorrhagia.In this study, the antibacterial activity of Iranian snake Echis carinatus venom against six different bacteria (Staphylococcus aureus, Methicillin Resistant Staphylococcus aureus (MRSA), Listeria monocytogenes, Bacillus subtilis, Salmonella typhimurium and Escherichia coli O157:H7), were investigated. Crude venom (100μg/ml) and different standard antibiotic disks as positive controls were tested by the gel diffusion method. Since the results showed that Echis carinatus venom has a significant antibacterial effect against S. aureus and MRSA, the minimum inhibitory concentrations (MIC) were also determined for these two susceptible bacteria: this was 80μg ml-1 against both strains. Also, the results determined that Echis carinatus venom dose not have a noticeable effect on other tested bacteria

کلمات کلیدی:
antibacterial, venom, Echis carinatus

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