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گواهی نمایه سازی مقاله Histopathological evaluation of the effect of platelet-rich fibrin on canine cutaneous incisional wound healing

عنوان مقاله: Histopathological evaluation of the effect of platelet-rich fibrin on canine cutaneous incisional wound healing
شناسه (COI) مقاله: JR_IJVST-5-2_005
منتشر شده در دوفصلنامه علوم و فنون دامپزشکی ایران در سال ۱۳۹۲
مشخصات نویسندگان مقاله:

Majid Khanzadeh AlishahiP - PResearch Institute of Animal Breeding and Genetics, Abbas Abad, Mashhad, Iran
Davoud KazemiP - PDepartment of Clinical Sciences, College of Veterinary Medicine, Tabriz Branch, Islamic Azad University, Tabriz, Iran
Darioush MohajeriP - PDepartment of Pathobiology, College of Veterinary Medicine, Tabriz Branch, Islamic Azad University, Tabriz, Iran
Hasan MofidpoorP - PDepartment of Anatomy, Mashhad University of Medical Sciences, Mashhad, Iran

خلاصه مقاله:
Platelets are a natural source of growth factors and cytokines that promote wound healing, and platelet-rich fibrin contains concentrated growth factors. Growth factors in platelet-rich fibrin may promote wound repair. In this study the effect of platelet-rich fibrin was evaluated in a dog model of cutaneous incisional wounds using histology and semi-quantitative evaluation. One pair of ten-centimeter full-thickness parallel linear cutaneous wounds were created on the backs of 15 dogs on the both sides of vertebral column. On the left side the platelet-rich fibrin clot was applied to the edges of the wound (Treatment group) and the right side received nothing (Control group). All wounds were then closed with 3-0 non-absorbable Nylon suture. The dogs were divided into three groups of five dogs. The wound tissues were sampled by electrosurgery in group one after 3 days, group two after 7 days and group three after 14 days post surgery. For each specimen, histopathological examination and semi-quantitative evaluation was performed by light microscopy using Hematoxylin & Eosin and Masson’s trichrome staining. The results demonstrated that platelet-rich fibrin improved and accelerated cutaneous incisional wound healing

کلمات کلیدی:
Platelet-rich fibrin, wound healing, cutaneous wound

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