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گواهی نمایه سازی مقاله The Inhibition Effects of Two Species of Astragalus Extracts on Mushroom Tyrosinase Activity

عنوان مقاله: The Inhibition Effects of Two Species of Astragalus Extracts on Mushroom Tyrosinase Activity
شناسه (COI) مقاله: JR_JABR-1-2_004
منتشر شده در فصلنامه گزارش های زیست فناوری کاربردی در سال ۱۳۹۳
مشخصات نویسندگان مقاله:

Azadeh Taherian - Department of Biology, School of Science and Agriculture, Payame Noor University of Tehran, Tehran, Iran
Alireza Jahangiri - Department of Medicinal Chemistry, School of Pharmacy, Ahwaz Jundishapur University of Medical Sciences, Ahwaz, Iran
Forogh Namjoyan - Department of Pharmacognosy, School of Pharmacy, Ahwaz Jundishapur University of Medical Sciences, Ahwaz, Iran
Seyed Reza Hajhosseini - Department of Biology, School of Science and Agriculture, Payame Noor University of Tehran, Tehran, Iran

خلاصه مقاله:
Melanin pigment plays a critical role in camouflage and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory control bymultiple agents. Tyrosinase is a multifunctional, which catalyzes the first two steps in mammalian melanogenesis. In this study, inhibitory effects of Astragalus fasciculifolius and Astragalus gypsicolus on diphenolase activity of mushroom tyrosinase were evaluated. .Ethanol 80% extracts were prepared for screening tests. The IC50,Ki, Km and Vm values of Astragalus fasciculifolius and Astragalus gypsicolus were measured then compared them. We found that Both extracts show mixed type inhibition on mushroom tyrosinase when L-DOPA was used as a substrate

کلمات کلیدی:
Tyrosinase Inhibitor, Astragalus fasciculifolius, Astragalus gypsicolus

صفحه اختصاصی مقاله و دریافت فایل کامل: https://www.civilica.com/Paper-JR_JABR-JR_JABR-1-2_004.html