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گواهی نمایه سازی مقاله Mechanisms and Performances of Adjuvants in Vaccine Immunogenicity

عنوان مقاله: Mechanisms and Performances of Adjuvants in Vaccine Immunogenicity
شناسه (COI) مقاله: JR_JABR-2-3_003
منتشر شده در فصلنامه گزارش های زیست فناوری کاربردی در سال ۱۳۹۴
مشخصات نویسندگان مقاله:

Seyed Mohammad Gheibihayat - Young Researchers and Elite Club, Andimeshk Branch, Islamic Azad University, Andimeshk, Iran
Azam Sadeghinia - Department of Cardiology, Faculty of Medicine, Dezful University of Medical Sciences, Dezful, Iran
Shahram Nazarian - Department of Biology, Faculty of Science, Imam-Hossein University, Tehran, Iran
Zahra Adeli - Department of Microbiology, Islamic Azad University, Damghan Branch, Damghan, Iran

خلاصه مقاله:
An adjuvant is a substance that is added to a vaccine to increase the body's immune response to the vaccine. Vaccines containing adjuvants are tested for safety inclinical trials before they are licensed for use. The basic action of adjuvants is stimulating adaptive immune responses. Adjuvants recently licensed for humanutilization involve alum squalane oil or water emulsion, influenza virosomes, and few cytokines as IFN-γ and IL-2. Some adjuvants are currently under investigationsuch as DNA motifs, monophosphoryl lipid A, Cholera Toxin, E. coli heat Labile Toxin, Saponins, Immunostimulating complexes, liposomes, Flt3 ligand as a pleotropic glycoprotein, non-ionic block copolymers. This paper is an overview of most commonly used adjuvants, adjuvant mechanisms, adjuvant formulations and adjuvant limitations

کلمات کلیدی:
Adjuvants, Vaccine, Immunostimulating Complexe, Alum, MHC

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