Farzaneh Mohamadpour - Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P. O. Box 98135-674 Zahedan,Iran
Malek Taher Taher Maghsoodlou - Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P. O. Box 98135-674 Zahedan,Iran
Reza Heydari - Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P. O. Box 98135-674 Zahedan,Iran

In this protocol, we have reported Nano Zeolite as an efficient and environmentally benign nature catalyst for the multi-component efficient synthesis of biologically spirooxindole derivatives. And we studied three-component, one-pot condensation of isatin/acenaphthequinone, malononitrile and different reagents including 1, 3-dicrbonyl compounds, naphthol and 4-hydroxycumarin under thermal and solvent-free conditions in the presence of Nano Zeolite as a mild catalyst. solvent-free conditions, short reaction times, good yields, non-toxic, in expensive, simple operational procedures, one-pot, mild, easily separated from the reaction mixture with no column chromatographic separation for the economical synthesis of these fused biologically compounds are the major advantages of this literature.

Nano Zeolite, Spirooxindole derivatives, Multi-component reactions, Solvent-free conditions