Farzaneh Mohamadpour - Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P. O. Box 98135-674 Zahedan, Iran
Malek Taher Maghsoodlou - Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P. O. Box 98135-674 Zahedan, Iran
Reza Heydari - Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P. O. Box 98135-674 Zahedan, Iran

In this protocol, we have reported an efficient, simple and environmentally benign nature methodology for the synthesis of substituted dihydro-2-oxypyrrole via a one-pot four-component domino condensation of dialkyl acetylenedicarboxylate, formaldehyde and amines (aromatic and aliphatic) under ambient temperature with excellent yields and short reaction times. Nano SiO2 has been used as a mild, economical and environmentally friendly catalyst for preparation of substituted dihydro-2-oxypyrrole. The environmentally benign nature, simple, inexpensive and non-toxic catalyst, easily separated with no column chromatographic separation, high catalytic activity, highly efficient is an option for the simple synthesis of these rings.

Nano SiO2, Dihydro-2-oxypyrrole derivatives, Multi-component reaction, Efficient methodology