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گواهی نمایه سازی مقاله A highly efficient synthesis of biologhically active spirooxindole derivatives with Nano SiO2 as a mild catalyst under solvent-free conditions

عنوان مقاله: A highly efficient synthesis of biologhically active spirooxindole derivatives with Nano SiO2 as a mild catalyst under solvent-free conditions
شناسه (COI) مقاله: MINMETALCONF01_066
منتشر شده در کنفرانس بین المللی مهندسی معدن، فلزات و مواد در سال ۱۳۹۴
مشخصات نویسندگان مقاله:

Farzaneh Mohamadpour - Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P. O. Box 98135-674 Zahedan, Iran
Malek Taher Maghsoodlou - Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P. O. Box 98135-674 Zahedan, Iran
Reza Heydari - Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P. O. Box 98135-674 Zahedan, Iran

خلاصه مقاله:
In this protocol, we have reported Nano SiO2 as an efficient and environmentally benign naturecatalyst for the multi-component efficient synthesis of biologically spirooxindole derivatives. And we studied three-component, one-pot condensation of isatin/acenaphthequinone, malononitrile and different reagents including 1, 3-dicrbonyl compounds, naphthol and 4-hydroxycumarin under thermal and solvent-free conditions in the presence of Nano SiO2 as a mild catalyst. solvent-free conditions, short reaction times, good yields, non-toxic, in expensive, simple operational procedures, one-pot, mild, easily separated from the reaction mixture with no column chromatographic separation for the economical synthesis of these fused biologically compounds are the major advantages of this literature.

کلمات کلیدی:
Nano SiO2, Spirooxindole derivativesm Multi-component reactions, Solvent-free conditions

صفحه اختصاصی مقاله و دریافت فایل کامل: https://www.civilica.com/Paper-MINMETALCONF01-MINMETALCONF01_066.html