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گواهی نمایه سازی مقاله Application of UV-Spectrophotometry and HPLC method for determination of Zonisamide and its four related substances in medical science

عنوان مقاله: Application of UV-Spectrophotometry and HPLC method for determination of Zonisamide and its four related substances in medical science
شناسه (COI) مقاله: NCCEESLAMSHAR01_175
منتشر شده در همایش ملی مهندسی شیمی در سال ۱۳۸۸
مشخصات نویسندگان مقاله:

Maryam Hosseini - Young researchers club, Islamic Azad University, North Tehran branch, Tehran, Iran.
Eskandar Alipour - Faculty of Chemistry, Islamic Azad University, North Tehran branch,Tehran,Iran.
Erfan Ziarifar - Young researchers club,Islamic azad University of Ahwaz

خلاصه مقاله:
A selective and sensitive liquid chromatographic method has been developed for simultaneous determination of zonisamide and its four related substances in pharmaceutical dosage forms. The assay involved an isocratic elution in perfectsil Target C18 column using a mobile phase composition of Disodium hydrogen phosphate buffer, Acetonitril and methanol (650: 150: 200 v/v, pH adjusted to 3 ± 0.05) with flow rate 1.2 ml / min and analyte monitored at 240 nm. Also a simple and precise spectrophotometric method was developed for dissolution studies. These proposed methods are sensitive, accurate, reproducible and useful for the routine determination of zonisamide in medical.

کلمات کلیدی:
zonisamide; liquid chromatography; UV spectrophotometry; impurities; medical science

صفحه اختصاصی مقاله و دریافت فایل کامل: https://www.civilica.com/Paper-NCCEESLAMSHAR01-NCCEESLAMSHAR01_175.html