Application of UV-Spectrophotometry and HPLC method for determination of Zonisamide and its four related substances in medical science
عنوان مقاله: Application of UV-Spectrophotometry and HPLC method for determination of Zonisamide and its four related substances in medical science
شناسه ملی مقاله: NCCEESLAMSHAR01_175
منتشر شده در همایش ملی مهندسی شیمی در سال 1388
شناسه ملی مقاله: NCCEESLAMSHAR01_175
منتشر شده در همایش ملی مهندسی شیمی در سال 1388
مشخصات نویسندگان مقاله:
Maryam Hosseini - Young researchers club, Islamic Azad University, North Tehran branch, Tehran, Iran.
Eskandar Alipour - Faculty of Chemistry, Islamic Azad University, North Tehran branch,Tehran,Iran.
Erfan Ziarifar - Young researchers club,Islamic azad University of Ahwaz
خلاصه مقاله:
Maryam Hosseini - Young researchers club, Islamic Azad University, North Tehran branch, Tehran, Iran.
Eskandar Alipour - Faculty of Chemistry, Islamic Azad University, North Tehran branch,Tehran,Iran.
Erfan Ziarifar - Young researchers club,Islamic azad University of Ahwaz
A selective and sensitive liquid chromatographic method has been developed for simultaneous determination of zonisamide and its four related substances in pharmaceutical dosage forms. The assay involved an isocratic elution in perfectsil Target C18 column using a mobile phase composition of Disodium hydrogen phosphate buffer, Acetonitril and methanol (650: 150: 200 v/v, pH adjusted to 3 ± 0.05) with flow rate 1.2 ml / min and analyte monitored at 240 nm. Also a simple and precise spectrophotometric method was developed for dissolution studies. These proposed methods are sensitive, accurate, reproducible and useful for the routine determination of zonisamide in medical.
کلمات کلیدی: zonisamide; liquid chromatography; UV spectrophotometry; impurities; medical science
صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/80184/