Shirin Shahraki - Shahrakia, Mahboubeh Masrourniaa, *, Hassan Karimi-Malehb a Department of Chemistry, Mashhad Branch, Islamic Azad University, Mashhad, Iran
Mahboubeh Masrournia - Shahrakia, Mahboubeh Masrourniaa, *, Hassan Karimi-Malehb a Department of Chemistry, Mashhad Branch, Islamic Azad University, Mashhad, Iran
Hasan Karimi-Maleh - Department of Chemical Engineering, Laboratory of Nanotechnology, Quchan University of Technology, Quchan, Islamic Republic of Iran

Sulfapyridine is one of the most important antibiotics drug with some side effects and determination of this drug is very important in biological and pharmaceutical samples. In this research, an electrochemical amplified sensor was fabricated as analytical tool for determination of sulfapyridine in drug samples. For fabrication of sulfapyridine sensor, a carbon paste electrode (CPE) was amplified with copper oxide decorated single wall carbon nanotubes (CuO/SWCNTs) as conductive mediator. The CuO/SWCNTs/CPE was used for voltammetric determination of sulfapyridine and results showed an increasing in oxidation current sulfapyridine about 2.35 times and decreasing 80 mV in oxidation potential in the same condition. The cyclic voltammetric (CV) investigation confirm pH dependent redox reaction for sulfapyridine in the presence of one electron and one proton with maximum sensitivity at pH=7.0. Analytical investigation showed a linear dynamic range 50 nM- 400 µM with detection limit 10 nM. In the final step, CuO/SWCNTs/CPE was used for determination of sulfapyridine in tablet, drinking water and dextrose saline sample with acceptable recovery data between 99.13% - 103.35%.

Sulfapyridine, CuO/SWCNTs composite, Modified electrode, Electrochemical sensor