فاطمه قانع - Department of Chemistry, Darab branch, Islamic Azad University, Darab, Iran
پگاه رسولی - Department of Chemistry, Fasa branch, Islamic Azad University, Fasa
بنفشه خنجری - Department of Chemistry, Darab branch, Islamic Azad University, Darab, Iran
علیرضا یوسفی - Department of Pathology, Faculty of Veterinary Medicine, Kazerun Branch, Islamic Azad University, Kazerun, Iran
علی زارع نژاد - Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran
حسین فتاحی - Department of Microbiology, Faculty of Veterinary Medicine, Kazerun Branch, Islamic Azad University, Kazerun, Iran
مهسا رستمی چایجان - Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran
عبدالمجید قاسمیان - Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran
بهنوش میلادپور - Department of Clinical Biochemistry, Fasa University of Medical Sciences, Fasa, Iran
الهام زارع نژاد - Noncommunicable Diseases Research Center, Fasa University of MEdical Sciences, Fasa, Iran

Background & Objective: Burn is one of the prominent causes of death around the world, however drug discovery attempts for burn healing has not been entirely successful. Aloe arborescens (A. arborescens), is effective in the burning wounds healing and growth inhibition of bacterial pathogens. Our objective was to assess the wound healing and antibacterial effects of A. arborescens in vivo. Materials & Methods: Thirty healthy Wistar rat animals were enrolled. The treatment process continued for ۲۱ days and sampling was conducted on days ۱۴ and ۲۱ and the tissue slides were sent to the pathology laboratory for testing. The bactericidal activity of A. arborescens extract was evaluated using the disc diffusion method. Results: A. arborescens demonstrated a significant effect on the healing of burn wounds. Furthermore, the antibacterial effects of the A. arborescens extract against Gram-negative (Escherichia coli, Pseudomonas aeruginosa) was significantly higher than that against Gram-positive (Staphylococcus aureus, Bacillus cereus) bacterial species. Conclusion: In conclusion, this study indicated that A. arborescens extract had an improving effect on the healing process of third degree burns without toxicity to the tissue.

Wound healing, Burns, Herbal Medicines, Aloe Arborescens, in vivo