Mehdi Mameneh - Faculty Member of Paramedical School, Ilam University of Medical Sciences, Ilam, Iran.
Seyed Amirreza Akhlagh - Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
Pouya Sharifi - Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran.
Samaneh Dabagh fekri - Department of Midwifery, School of Nursing and Midwifery, Ardabil University of Medical Sciences, Ardabil, Iran.
Fahimeh Khorasani - Student Research Committee, Kerman University of Medical science, Kerman, Iran.
Neda Asadi - Student Research Committee, Kerman University of Medical science, Kerman, Iran.
Farzane Ashrafinia - Student Research Committee, Kerman University of Medical science, Kerman, Iran.
Saba Safavi - Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.

Background Neonatal sepsis is a critical condition caused by a generalized bacterial infection in the first month of life. The present study aimed to investigate the relationship between serum vitamin D levels and neonatal sepsis. Materials and Methods: A search of online databases (Medline, Cochrane Library, Web of Science, EMBASE-Ovid, and Scopus) were carried out for randomized control trials and non-randomized prospective or retrospective clinical studies published in English till April ۲۰۲۰. Two reviewers selected the studies. Results: In the first study, the level of ۲۵-hydroxyvitamin D [۲۵(OH)D] in the cord-blood sample of infants in the Early-Onset Neonatal Sepsis (EONS) group was significantly lower compared to the control group. ۲۵(OH)D level (۱۹ ng/ml) in the control group were significantly higher compared to the ۲۵(OH) level (۸.۶ ng/ml) in the sepsis group. In the third study, the serum ۲۵(OH) level showed a significant decrease in the affected neonates (۶.۴ nmol/L) compared to healthy neonates (۴۲.۵ nmol/L). In the fourth study, the sepsis and control group had a significant difference in the level of ۲۵(OH)D (۶۹±۷.۵ng/ml and ۳۵±۱۹ng/ml). According to the fifth study, the serum ۲۵(OH)D level was insufficient in the case group and sufficient in the control group (p <۰.۰۰۰۱). In the sixth study, the odds of very-early-onset neonatal sepsis among the neonates who had the serum ۲۵-hydroxyvitamin D deficiency were lower compared to the odds among neonates who did not have serum ۲۵-hydroxyvitamin D deficiency. Conclusion The level of ۲۵-hydroxyvitamin D in the blood sample of infants in the sepsis group was significantly lower compared to the control group; further studies required to confirm the results by considering more confounders.

Infants, Sepsis, Neonatal Intensive Care Unit, Vitamin D