Neda MotamediRad
Meysam Rezaeishamirzadi
Seyyed Hamid Moosavy
Mohammad Shekari

Introduction: Helicobacter pylori is the main cause of chronic inflammation and peptic ulcer. More than half of the world population is afflicted with Helicobacter, while only ۲۰% of people show the clinical symptoms of the disease. Genes encoding the cytokines interleukin (IL)-۱B play a key role in the inflammatory responses of gastric mucus. This study aims to analyze polymorphism in the IL-۱B gene. Methods: ۱۰۷ individuals who showed the symptoms of chronic gastritis participated in the treatment group. Individuals with no symptoms were considered as the control group. IL-۱B+۳۹۵۴C/T polymorphism was analyzed through PCR-RFLP. Results: There is no association between the presence of the T allele in an IL-۱B gene whit peptic ulcer and chronic gastritis as compared with control group (OR=۰.۶۶, CI=۰.۳۴-۱.۲۷, OR=۰.۷۵, CI=۰.۳۲-۱.۱۵) respectively. Conclusion: Our results suggest that there is no association between IL-۱B+۳۹۵۴ C/T polymorphism and peptic ulcer disease and chronic inflammation.

Polymorphism, Interleukin ۱B, Peptic Ulcer, Gastritis, Polymorphism, Interleukin ۱B, Peptic Ulcer, Gastritis