Abbas Andishmand - Yazd Cardiovascular Research Center, Non-communicable Diseases Research Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Fatemah Sadat Mirzadeh - Tehran University of Medical Sciences, Ziaeian Hospital, Tehran,Iran
Masoud Mirzaei - Yazd Cardiovascular Research Center, Non-communicable Diseases Research Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Seyed Mostafa Seyed Hossaini Tezerjani - Yazd Cardiovascular Research Center, Non-communicable Diseases Research Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Mojtaba Mirzadeh - Shahid Beheshti University of Medical Sciences, Taleghani Hospital, Tehran, Iran

Objectives: A positive family history of Sudden Cardiac Death (SCD) is an independent risk factor for mortality. This study aimed to determine the prevalence of a positive family history of SCD and its associated risk factors among victims of sudden death in Yazd. Methods: This cross-sectional study investigated SCD cases in Yazd, Iran, in ۲۰۱۱. The study included victims who were aged ۲۰ years or older, and the cause of death was the cardiac arrest within one hour of symptom onset. The data obtained from families of SCD victims through verbal autopsy interviews. Results: A total of ۳۱۷ cases of SCD occurred among victims, resulting in an incidence rate of ۱۳۹.۴ per ۱۰۰,۰۰۰ population ۲۶.۲% had a positive family history of SCD, with a mean age of ۶۰.۴ ± ۱۲.۳ years. Individuals with a positive family history of SCD had a significantly younger mean age at the time of death (۶۰.۹ ± ۱۲.۳ vs. ۶۶.۹ ± ۱۶.۵ years, P = ۰.۰۱۸). The prevalence of diabetes mellitus (odds ratio ۱.۴۳, CI ۹۵% = ۱.۰۳–۱.۹۹, P = ۰.۰۴۲), dyslipidemia (odds ratio ۱.۴۷, CI ۹۵% = ۱.۰۷–۲.۱, P = ۰.۰۳۸), chronic coronary artery disease (P =۰.۰۲۷), and revascularization (P = ۰.۰۴۹) had a significant association with positive family history of SCD. Conclusions: This study highlights the importance of assessing family history as a risk factor for SCD, along with other risk factors such as diabetes, dyslipidemia, and chronic coronary artery disease.

Sudden cardiac death, risk factor, family history, Coronary Artery Disease