Maryam Tavakkoli Lakeh - Department of Microbiology, Faculty of Basic Sciences, Lahijan Branch, Islamic Azad University (IAU), Lahijan, Iran.

Introduction: Hepatitis is an inflammation of the liver that causes pain and swelling. In the liver, blood waste is dismantled. When the liver is inflamed, your task is not doing well in cleaning the blood. Initial civilized societies in the area of Mesopotamia knew the liver is the heart of life. Because it seemed like, the liver is the accumulation of the blood in the body. Causes of the hepatitis are numerous. Hepatitis is caused mainly by one of the five hepatitis viruses. Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide. The aim of this study was to investigate the lesions of the liver and its relationship with Aflatoxin levels in serum samples of the patients with hepatitis B. Materials and methods: The study included 25 hepatitis-positive sera collected from hospitals in Rasht city and was tested by ELISA. Between 25 samples of which there were a total of Aflatoxin B (B1 and B2). Then the patients liver for the possible situation awareness and the effectiveness of Aflatoxin on the situation, using the results of ELISA and amounts of blood markers (ALT, AST, ALP, BIL) derived from the patients' blood test results, calculations help SPSS statistical software to analyze data and communicate and influence between the factors involved there. Results: A significant results occurred among a group of these factors, and activity of liver enzymes (ALT, AST, ALP) in hepatitis significantly increased over time, which can damage liver cells to approve or cholestasis. Also according to the conclusion that bilirubin testing, testing is not appropriate to assess the condition of the liver. Because usually the cause of the liver failure is changed. Conclusion: The amounts of Aflatoxin B obtained from the ELISA (hepatitis B and C synergistic effect of the toxin) were approved. The result can be total Aflatoxin B as a contributing factor in the progression of hepatitis.

Hepatitis, Degeneration in liver, Aflatoxin B