F Samiee Rad - Department of Pathology Department, Qazvin Metabolic Disease Research Center, Qazvin, Iran
F Talebi - MSc in Nursing, Kosar Hospital development and clinical research center, Qazvin University of Medical Sciences, Qazvin, Iran
A Nadjee - Department of Pathology Department, Qazvin University of Medical Sciences, Qazvin, Iran

Introduction: Hydatidiform mole is one of the gestational trophoblastic diseases that relatedto normal or abnormal pregnancies and results from compound error of fertilization.Evidenceof toxemia of pregnancy (hypertention,edema,albuminuria) is frequently found and thistypically occurs during the early stages of the pregnancy.Hyperthyroidism develops as aresult of a thyroid stimulator secreted by the molar tissue ,perhaps residing in the humanchorionic gonadotrophin (hCG) molecules itself.The present study was undertaken toevaluate the prevalence of thyrotoxicosis in Hydatidiform Molar pregnancy in the KosarHospital.Methods and materials : This was a cross-sectional and retrospective study conducted amongthe 113 pregnant women in first trimester that referred to prenatal clinic of the Kosar Hospital(during March 2005 to March 2012) with vaginal bleeding. Among them ,for patients thatcomplained from clinical manifestations of thyroid dysfunction, thyroid function tests wereperformed by ELISA(enzyme linked immunoassay) method. Both descriptive and statisticalanalysis methods were applied.Results: The mean ± SD of age of patients in our study population were 17.8 ± 2.6 years. Theprevalence of hyperthyroidism, that confirmed by thyroid function tests were 16(14.2%).Most common symptom was palpitation. Past medical history of molar pregnancies waspresent in fourteen (12.4%) patients.Conclusion: Removal of molar tissue caused a dramatic fall in the serum levels of T3, T4,molar TSH, and human chorionic gonadotrophin. The close correlation between the serumconcentrations of molar TSH and human chorionic gonadotrophin lend support to thesuggestion that the human chorionic gonadotrophin molecule itself, when present in largeamounts, stimulates thyroid function significantly.

Thyrotoxicosis, Hydatidiform Mole, pregnancy