Mohammed S.K Al-Bermani
Ahmed A. Mhawesh
Samia Kh. Mahmood

The rapid growth of using nanoparticles in different field of science, lead to the urgent necessitate to study the toxicpathology of this submicron particles. Layer Double Hydroxide NPs have qualified features such as biocompatibility, ion exchange and pH effect which make LDH NPs potential candidate for various biological applications such as drug delivery. Hence in this study Mg-Al LDH NPs have been prepared by coprecepetation method and injected intravenously. Twenty rats were divided in to two groups as following: Group I: Rats served as control and injected 1ml of distilled water intravenously for one month. Group II: Rats served as experimental and received by I/V injected in the tail vein 1ml of 0.00276 of Mg-Al LDH NPs g/ml. daily for one month. The size of LDH NPs have been measured by SEM which resulted size ranging between 50- 80 nm in diameter. The liver ,kidney, heart ,lung ,spleen and testes were examined histologically. The toxicopathological results were very sever in kidneys ,lung, spleen and heart, while were moderate in liver and testes .In general all organs showed necrotic changes with inflammatory cells infiltration ,congestion and thrombosis in blood vessels.

LDH, Toxicopathological study, Nanoparticles, Rat