Mahdi Barzegar - Student Research Committee, School of medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Reyhane Azarbayejani - Neurosciences Research Center, Alzahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
Vahid Shaygannejad - Student Research Committee, School of medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Background and Objective: Neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS) are associated with reduced Health Related Quality of Life (HRQOL). To the best of our knowledge, change of HRQOL in patients with NMOSD has not been yet measure in Iran. The objective of this study was to assess HRQOL in NMOSD and MS patients and identify related factors Materials and Methods: A cross sectional study of 41 patients with NMOSD and 136 age and sex-match MS patients was performed. A series of questionnaires including Persian validated questionnaires on HRQOL (SF-36), fatigue (MFIS), depression (BDI-II), anxiety (HAM-A) and sleep quality (PSQI) were record. All demographic variables, socioeconomic status and clinical data were also obtained. Student s T test and Mann–Whitney U test used to compare variables between groups and multivariate regression analysis applied to assay predictor factors. Findings: The mean scores of mental (MCS) and physical (PCS) components of QOL were statistically lower in patients with NMOSD compare with MS patients (β=-4.49, P=0.004; β=-3.52, P=0.015). Multivariate analysis indicated fatigue, depression and anxiety were independent, significant predictor of MCS (β=-0.229, P=0.002; β=-0.229, P=0.002; β=-0.258, P=0.020 respectively). However, PCS was significantly predicted by fatigue (β=-0.258 P<0.001), solely. Conclusion: These findings indicate NMOSD patients have lower HRQOL in compare to patients with MS. Also, screening and treatment of fatigue as the most important predictor for HRQOL is necessary.

Quality of life; Fatigue; Anxiety; Depression; Neuromyelitis optica spectrum disorder; Multiple sclerosis