neda fakhr almobasheri - Department of Biochemistry, Falavarjan Branch, Islamic Azad University, Isfahan, Iran
kahin shahanipour - Department of Biochemistry, Falavarjan Branch, Islamic Azad University, Isfahan, Iran
ramesh monajemi - Department of Biology, Falavarjan Branch, Islamic Azad University, Isfahan, Iran

Objective(s): Nanotechnology has enabled researchers to synthesize nanosize particles that possess increased surface areas. Compared to conventional microparticles, it has resulted in increased interactions with biological targets.The objective of this study was to determine the protective ability of selenium nanoparticles compared to selenium against parasetamol hepatotoxicity and GPX concentration. Materials and Methods: Seventy-two male rats were used in the study, and arbitrarily assigned to six groups. There were 12 rats in each group that six rat were tested in each period. Blood samples were collected from rats for measuring liver enzymes and GPX activity. Results: The present study shows that parasetamol has a toxic effect on the liver as a result of inducing a marked oxidative damage and release of reactive oxygen species. This was shown by the significant increases in ALP, AST, ALT and LDH activity which was accom­panied by significant decrease in GPX activity in the parasetamol -treated group compared to the control, selenium and selenium nanoparticles groups. There was no significant difference between selenium and selenium nanoparticles groups and two period time (15 and 30 day). Conclusion: selenium nanoparticles and selenium have protective against  paracetamol.

GPX activity, Hepatotoxicity, Parasetamol, Selenium nanoparticles