Mohamed Eddouks - Faculty of Sciences and Tecniques Errachidia, Moulay Ismail University, BP ۵۰۹, Boutalamine, Errachidia, ۵۲۰۰۰, Morocco
Ahmed Lemhadri - Faculty of Sciences and Tecniques Errachidia, Moulay Ismail University, BP ۵۰۹, Boutalamine, Errachidia, ۵۲۰۰۰, Morocco
Morad Hebi - Faculty of Sciences and Tecniques Errachidia, Moulay Ismail University, BP ۵۰۹, Boutalamine, Errachidia, ۵۲۰۰۰, Morocco
Ahmed EL Hidani - Faculty of Sciences and Tecniques Errachidia, Moulay Ismail University, BP ۵۰۹, Boutalamine, Errachidia, ۵۲۰۰۰, Morocco

Objective: As the aqueous extract of Capparis spinosa (CS) possess antidiabetic effect, he present study aims to reveal the possible  mechanism of action of CS in diabetic mice.Materials and Methods: Both single and repeated oral administrations of aqueous extract of CS were performed in multi-low dose streptozotocin-induced (MLDS) diabetic mice. Euglycemic hyperinsulinemic clamp was used in association with the endogenous glucose production (perfusion rate of 3-3H glucose) to evaluate the effect of CS aqueous extract on insulin sensitivity.Results: Our study showed that aqueous extract of CS possess a potent hypoglycaemic activity in MLDS diabetic mice. Furthermore, the analysis perfusion of 3-3H glucose demonstrated  the parallel decrease of basal endogenous glucose production (EGP) with the hypoglycaemic activity. EGP was lower in CS-Treated group when compared to the control group (p<0.001). The euglycemic hyperinsulinemic clamp technique demonstrated that CS treatment improves insulin sensitivity in peripheral tissues.Conclusion: We conclude that the antihyperglycemic effet CS is probably due to the inhibition of basal endogenous glucose production and the improvement of insulin sensitivity in MLDS diabetic mice.

Diabetes, Streptozotocin, Insulin sensitivity, Mice