Rahim Nejadrahim - MD, Assistant Professor, Department of Infectious Diseases, Faculty of Medicine, Urmia University of Medical Sciences, Iran.
Pouya Hosseinzadeh - Nursing student, Islamic Azad University of Medical Sciences, Urmia, Iran.
Salar Javanmard barbin - Nursing student, Islamic Azad University of Medical Sciences, Urmia, Iran
Zahra Mousavi - Midwifery student, Islamic Azad University of Medical Sciences, Urmia, Iran
Saeed Kazem alilu - Medical student, Urmia University of Medical Sciences, Iran

Background: Diabetic foot ulcers (DFUs) is a major health problem, which concerns 15% patients with diabetes worldwide. Major amputation, above or below the knee, is a feared complication of Diabetes. Costs related to DFUs care are greater than $1 billion annually and rising. Few studies have identified factors as predictors of clinical prognosis of patients with DFUs, especially of Iranian patients. In this study, we assessed the prognostic factors of Iranian patients with DFUs. Methods and Materials: Prospective cohort hospital based study conducted in Patients with Diabetic foot ulcer from June 2015 - June 2016. Diagnosis of Diabetic foot ulcer was based on WAGNER – MEGGITT criteria and patients with grade 2 and more were evaluated. Patients were followed up for three months in order to determine the desired outcome (recovery or amputation). Data collection was done by checklist design and lipid profile (Triglyceride, Cholesterol, HDL-C, LDL-C) and inflammatory biomarker (ESR and CRP levels) were entered to the checklist. All statistical calculations and analyses were performed by using SPSS software (version 16). P value of less than 0.05 was considered significant.Results: In total, the study included 72 patients with DFUs and 58.3% of the patients were man. Mean age of the patients was 59.19+/- 11.94 years and mean duration of diabetes was 15.52+/- 8.62. The majority of patients (94.8%, 68 cases) had type 2 diabetes mellitus. 70.8% had ESR> = 50, 35.9% had CRP> = 3+, 95.6% had HbA1C > =7, 58.6% had LDL> 100, 95.5% had HDL<50 and 67.2% had TG<200. Follow up time was 3 months from hospital discharge. The overall limb amputation rate in the current study was 21.3%.Discussion: Our results demonstrated that limb amputation rate is not correlated with sex, duration of diabetes, ESR, HbA1c, WBC, LDL, HDL. Significant univariate predictive factors for limb amputation was CRP level and Triglyceride level. (p= 0.91, p= 0.064 respectively) .

Diabetes, Amputation, Risk factors, Epidemiology