Electrochemical Amplified Sensor with Mgo Nanoparticle and Ionic Liquid: A Powerful Strategy for Methyldopa Analysis

In this research, an amplified sensor based on paste electrode (PE) modified with MgO nanoparticle (MgO/NPs) and ۱-hexyl-۳-methylimidazolium hexafluorophosphate (HMH) was designed and used for determination of methyldopa (MD). The CP/MgO/NPs/HMH showed good catalytic activity toward oxidation of MD and improved drug current about ۳.۵۸ times. In addition, CP/MgO/NPs/HMH showed a diffusion process and pH dependence behavior for electro-oxidation of MD in aqueous solution. However, differential pulse voltammogram of CP/MgO/NPs/HMH showed a linear dynamic range to sensing of MD in concentration range ۱.۰ nM – ۴۰۰ µM with detection limit ۰.۵ nM. The recovery range ۹۸.۲۵% - ۱۰۲.۵% was obtained for sensing of MD in real samples using CP/MgO/NPs/HMH.    

کلیدواژه ها:

Methyldopa ، MgO nanoparticle ، Ionic Liquid ، ۱-hexyl-۳-methylimidazolium hexafluorophosphate ، Sensor