Nasal Carriage Frequency and Antibiotic Resistance Pattern of Methicillin-Resistant Staphylococcus aureus Isolates from Operating Room Personnel of Valieasr Hospital, Qaemshahr, Iran

Introduction: Staphylococcus aureus is recognized as a significant pathogenic agent in human diseases. Nasal carriage of Staphylococcus aureus is an independent risk factor for hospital-acquired infections, particularly surgical site infections. This study aimed to investigate the frequency and antibiotic resistance pattern of S. aureus strain isolates from the nasal carriage of operating room personnel in a referral hospital in Qaemshahr. Material and Methods: This study was conducted on ۶۵ personnel in the surgical and operating room departments (morning, evening, and night shifts) in ۲۰۲۲. The sampling method was census-based, and a checklist containing demographic information, underlying diseases, work history, history of antibiotic use, etc., was employed. Results: The result of nasal swab culture in ۱۰ individuals (۱۵.۴%) was positive. Also, the results showed a higher carrier frequency in the age group over ۴۰ years (۲۱.۷%), among males (۲۲.۶%), in the nursing profession (۱۵.۵۶%), in personnel with more than ۱۰ years of experience in the surgical department (۲۴%), and with a work history in the hospital exceeding ۱۳ years (۲۵%). Furthermore, the results indicated higher sensitivity to rifampin and cefazolin in this descriptive study. Regarding clindamycin and oxacillin, relative sensitivity was observed. Conclusion: In general, the results indicated that antibiotic resistance to ciprofloxacin, trimethoprim-sulfamethoxazole, erythromycin, clindamycin, and oxacillin was higher in Staphylococcus aureus infections. Therefore, it is suggested to investigate the causes of antibiotic resistance to these drugs to prevent further resistance compared to other antibiotics.

کلیدواژه ها:

Nasal Carriers ، Antibiotic Resistance ، Staphylococcus Aureus