Application of ZnO nanoparticles ionic liquids modified electrode as a sensor for determination of promazine

Promazine is a medication that belongs to the phenothiazine class of antipsychotics. An older medication used to treat schizophrenia; it is still prescribed, alongside newer agents such asolanzapine and quetiapine. It has predominantly anticholinergic side effects, though extra pyramidal side effects are not uncommon either. The monitoring of promazine is significant for quality assurance in the pharmaceutical industry and for obtaining optimum therapeuticconcentrations in body fluids to minimize the risk of toxicity [1]. Therefore, determination of this drug is important in biological compound such as urine and drug. In this work we describe the first report for determination of promazine using a nanostructure modified ionic liquid carbon paste electrode in the aqueous solution. For this goal, a novelmodified carbon paste electrode with ZnO nanoparticle and 1-methyl-3-butylimidazolium bromide as a binder (ZnO/NPs/ILs/CPE) was fabricated. The oxidation peak potential of promazine at the surface of the ZnO/NPs/ILs/CPE appeared at 685 mV, which was about 65 mV lower than the oxidation potential at the surface of CPE under similar conditions. Also, the peakcurrent was increased to about 4.0 times at the surface of ZnO/NPs/ILs/CPE compared to CPE. The linear response range and detection limit were found to be 0.08–450 and 0.04 μmol/L,respectively. The modified electrode was successfully used for the determination of promazine in real samples with satisfactory results. The XRD pattern of ZnO/NPs, in the 2θ range of 10–90°, is shown in Fig. 1A. Typical SEM micrograph of the ZnO/NPs is shown in Fig. 2B.

کلیدواژه ها:

Promazine ، ZnO nanoparticle ، Ionic liquids ، Voltammetric analysis