Application of mathematics models ni engineering sciences
سال انتشار: 1395
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 592
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شناسه ملی سند علمی:
THCONF01_049
تاریخ نمایه سازی: 18 تیر 1396
چکیده مقاله:
Mathematical modeling is being increasingly recognized within the biomedical sciences as an important tool that can aid the understanding of biological systems. The heavily regulated cell renewal cycle in the colonic crypt provides a good example of how modeling can be used to find out key features of the system kinetics, and help to explain both the breakdown of homeostasis and the initiation of tumorigenesis. We use the cell population model by Johnston et al.5 to illustrate the power of mathematical modeling by considering two key questions about the cell population dynamics in the colonic crypt. We ask: how can a model describe both homeostasis and unregulated growth in tumorigenesis; and to which parameters in the system is the model most sensitive In order to address these questions, we discuss what type of modeling approach is most appropriate in the crypt
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نویسندگان
Parivash Shams Derakhsh
PhD student in applied mathematics Islamic Azad University, Tabriz – Iran
Sadegh Seidbeigi
PhD student in geography and urban planning Islamic Azad University, Science and Research Branch of Tehran – Iran
parisa Shams Derakhsh
PhD student in applied mathematics Islamic Azad University, Tabriz – Iran.