Combination of Silver Nanoparticles with some new Monocyclic β-Lactams

The scientists have been very interest in β-lactam compounds since the 1940s, when the antibiotic properties of the first semisynthetic the penicillins were discovered.1 In the late 1970s and early 1980s, several monocyclic β-lactams with high antibacterial activity have been discovered in nature. It was believed that the biological activity of β-lactams is absolutely correlated to functional groups on 2-azetidinone ring.2 Different research group studied biological activities of silver nanoparticles (AgNPs),3 and also synthesized AgNPs combined with some antibiotics4 as well as investigation of their antimicrobial activity. Our interest in β-lactam chemistry led us to study synthesis of some new β-lactams bearing morpholine ring and combination of some amino β-lactams with silver nanoparticles (Fig 1). The cycloadducts were characterized by spectral data, including 1H-NMR, 13C-NMR, IR, Mass spectroscopy and elemental analyses.

کلیدواژه ها:

β-Lactam ، [2+2] Cycloaddition Staudinger reactions ، Morpholine ، Silver nanoparticles (AgNPs)